Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.



Visit this page to stay up to date with the latest developments in organic synthesis. Simon Pearce, Market Segment Manager for Organic Reagents with Thermo Fisher Scientific, draws on over 30 years experience in the industry to provide his insights on the hot topics to watch. This page features regular articles, blogs, videos and posters to help you keep up with the industry trends that matter to your research. 

Simon Says   Named Reactions
organic chemistry blog   Simon Pearce organic chemistry blog

Visit summaries of Simon's recent blog posts



Welcome to our series of articles on key transformations in organic chemistry. The series starts with named reactions, i.e, chemical transformations named after their discoverers. Examples, among others, are: Friedel-Crafts reaction, Fries rearrangement, Gabriel synthesis, Baeyer-Villiger oxidation, Fischer indole synthesis, Knorr pyrrole synthesis, Heck reaction, Negishi cross-coupling reaction, Dess-Marti noxidationJones oxidation, Grignard reaction,  Clemmensen reduction, Heck reaction,  and Overman rearrangement.

Featured to date are named reactions that can be classified under one of the following reaction categories:


Two-Sided Poster    
periodic table - heterocyclic rings poster    

This back-to-back poster is a handy reference to the elements and heterocyclic ring systems. Hang it in your office or your lab.

Request your printed copy

Recent Articles

/media/library/4b75a220046742aeb12d721f2458c354.png   /media/library/1f378f9c5d8842e687a2811ec0d6aa3f.png
A Resurgence in Natural Product-Based Drug Discovery   Rational Drug Design: How Far Have We Come?

Over the past few decades, the influence of natural products on drug discovery has notably reduced. Here, Simon considers how advances in technology and adoption of alternative screening strategies are playing a role in revitalizing natural product-based drug discovery and bringing about a resurgence of interest in the inclusion of natural products and their substructures in compound screening collections.


Read full article here...


From the early use of Hansch parameters and Topliss Trees to today’s computational structure–activity techniques, medicinal chemists have long sought to rationalise drug design to find the quickest and most resource-efficient route to market. But, according to Simon, while modern strategies are more reliant on statistical algorithms and vast data libraries, these founding principles remain at their core.


Read full article here...


/media/library/cedee05a9b734204ac2509424602fd2e.jpg   heterocyclic compounds in anti-cancer drug design

Beyond the Rule of Five

The Importance of Heterocyclic Compounds in Anti-cancer Drug Design

Two decades on from its initial publication, Lipinski’s “rule of five” is arguably one of the most influential concepts in modern drug discovery. Yet it is also one of the most controversial. Lipinski’s rules have had a lasting effect on drug discovery strategies and the curation of compound screening libraries. Simon discusses why we need to explore the chemical space beyond Lipinski's rules.

Read full article here...


Simon looks at some of the most important heterocyclic compounds currently implicated in cancer therapy, discusses the properties that make them valuable as anti-cancer drugs, and considers the benefits of including heterocycles in high-throughput screening libraries as a way to fast-track the drug development process.

Read full article here...

drug development


Drug Development Doesn’t Always Have to Start From Scratch

Simon discusses an increasingly popular drug development strategy that involves repurposing previously developed drugs for new therapeutic purposes. He also shows how developers can use screening libraries to bypass many of the stages in drug development and access the untapped potential of existing drug molecules.

Read full article here...




Life Science

Metals & Materials


Analytical & Labware